Latest on Lupus Clinical Trials

Clinical trials help to answer the question, “Will this drug help people and be safe to take?”

At any given time, there are thousands of clinical trials going on. And finally, there are increasing numbers of lupus clinical trials.

Clinical trials are critical in the search for a better life for people with lupus.

Could You Be Part of the Solution?

Find out on our special Web site, LupusTrials.org.

What Are They Showing?

See the latest in results of clinical trials as they are reported in medical journals on the U.S. National Library of Medicine’s vast database of biomedical articles (PubMed). Some interesting ones from recent months include:

Impaired memory and learning abilities in patients with systemic lupus erythematosus as measured by the Rey Auditory Verbal Learning Test.
Ann Rheum Dis. 2009 Jun;68(6):812-6.

Abetimus sodium: a medication for the prevention of lupus nephritis flares.
Expert Opin Pharmacother. 2009 Jun;10(9):1501-7.

Pimecrolimus 1% cream versus betamethasone 17-valerate 0.1% cream in the treatment of facial discoid lupus erythematosus: a double-blind, randomized pilot study.
Clin Exp Dermatol. 2009 May 18.

Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort.
Arthritis Rheum. 2009 May;60(5):1496-507.

Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis.
J Am Soc Nephrol. 2009 May;20(5):1103-12.

The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus.
J Clin Invest. 2009 May;119(5):1066-73.

The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus.
J Clin Invest. 2009 May;119(5):1066-73.

EULAR points to consider for conducting clinical trials in systemic lupus erythematosus: literature based evidence for the selection of endpoints.
Ann Rheum Dis. 2009 Apr;68(4):477-83.

Update on immunotherapy for systemic lupus erythematosus--what's hot and what's not!
Rheumatology (Oxford). 2009 Apr;48(4):332-41

Effect of fluvastatin on cardiac outcomes in kidney transplant patients with systemic lupus erythematosus: a randomized placebo-controlled study.
Arthritis Rheum. 2009 Apr;60(4):1060-4.

Randomized, controlled trial of prednisone, cyclophosphamide, and cyclosporine in lupus membranous nephropathy.
J Am Soc Nephrol. 2009 Apr;20(4):901-11. Epub 2009 Mar 18.

Tibolone in postmenopausal women with systemic lupus erythematosus: a pilot study.
Maturitas. 2009 Mar 20;62(3):311-6.

An update on the use of mycophenolate mofetil in lupus nephritis and other primary glomerular diseases.
Nat Clin Pract Nephrol. 2009 Mar;5(3):132-42.

Use of rituximab in patients with systemic lupus erythematosus: an update.
Autoimmun Rev. 2009 Feb;8(4):343-8.

Use of rituximab in patients with systemic lupus erythematosus: an update.
Autoimmun Rev. 2009 Feb;8(4):343-8

Traditional and non traditional risk factors in accelerated atherosclerosis in systemic lupus erythematosus: role of vascular endothelial growth factor (VEGATS Study).
Autoimmun Rev. 2009 Feb;8(4):309-15.

The uncertain pathway to new therapeutics for SLE.
Lipsky PE. Nat Clin Pract Rheumatol. 2009 Feb;5(2):61.

The 10-year follow-up data of the Euro-Lupus Nephritis Trial comparing low-dose versus high-dose intravenous cyclophosphamide.
Ann Rheum Dis. 2009 Jan 20.

Monoclonal antibodies in the treatment of systemic lupus erythematosus.
Curr Drug Targets. 2009 Jan;10(1):26-37.

Gene therapy of the rheumatic diseases: 1998 to 2008.
Arthritis Res Ther. 2009;11(1):209

Monoclonal antibodies in the treatment of systemic lupus erythematosus.
Curr Drug Targets. 2009 Jan;10(1):26-37.

Use of pharmacogenetics, enzymatic phenotyping, and metabolite monitoring to guide treatment with azathioprine in patients with systemic lupus erythematosus.
J Rheumatol. 2009 Jan;36(1):89-95.

Sixth meeting of the European Forum on antiphospholipid antibodies. How to improve the understanding of the antiphospholipid syndrome?
Lupus. 2009 Jan;18(1):53-60.

Steroid-sparing effects of methotrexate in systemic lupus erythematosus: a double-blind, randomized, placebo-controlled trial.
Arthritis Rheum. 2008 Dec 15;59(12):1796-804.

Spliceosomal peptide P140 for immunotherapy of systemic lupus erythematosus: results of an early phase II clinical trial.
Arthritis Rheum. 2008 Dec;58(12):3873-83.

Ocrelizumab, a humanized monoclonal antibody against CD20 for inflammatory disorders and B-cell malignancies.
Curr Opin Investig Drugs. 2008 Nov;9(11):1206-15.

Belimumab, an anti-BLyS human monoclonal antibody for potential treatment of inflammatory autoimmune diseases.
Expert Opin Biol Ther. 2008 Nov;8(11):1805-14.

Update on the management of lupus nephritis: let the treatment fit the patient.
Nat Clin Pract Rheumatol. 2008 Sep;4(9):464-72.

Or search the database yourself—it’s pretty easy. Enter “lupus trial” in the Search bar.

New Medical Therapies (NMT) Trial Results from Thomson CenterWatch
The database provides information about the results of recently completed and ongoing clinical trials. Select Systemic Lupus Erythematosus.