Scripps Research Institute Scientists Find a Key Element of Lupus, Suggesting Better Drug Targets

A team led by scientists at The Scripps Research Institute (TSRI) has shown that blocking a particular pathway in lupus-triggering cells could be a way to fight the disease.

Results published in the online Early Edition of the Proceedings of the National Academy of Sciences the week of February 4, 2013 found that “the absence of a certain type of immune cell, or of a key signaling molecule within the cell, greatly reduces the development of autoimmunity in mouse models of lupus. Mice with these protective changes showed little impairment of their normal immune functions.”

Two highly respected members on the research team, Argyrios Theofilopoulos, PhD, and Dwight Kono, MD have served on the Peer Review Task Force to evaluate submissions for the Lupus Research Institute Novel Research Grants.