“Master Key” for Lupus Genes Could Lead to New Therapies

Using software designed at the Oklahoma Medical Research Foundation, researchers have identified a common factor present in many lupus-related genes.  OMRF scientists Marta Alarcon, M.D., Ph.D., and Mikhail Dozmorov, Ph.D.  found seven factors that affected a large number of genes. “Think about the genes like locks, which need keys to open,” said Dozmorov. “We were looking for a master key—something that affects all of these genes.”

Researchers hope these factors “will provide new targets for treating lupus and other autoimmune diseases.”  Published in the medical journal Epigenetics, the study was funded by grants from the National Institute of Allergy and Infectious Diseases and from the National Institute of General Medical Science, part of the National Institutes of Health.

Source: Oklahoma Medical Research Foundation