2009 General Immune System Function, New Treatments
Deletion of lupus autoreactive cells using an anti-hDR5 antibody
In lupus, immune system cells are mistakenly activated, causing attack against otherwise healthy organs and tissues. Would selectively eliminating these activated cells help stop or slow the disease—without causing toxic effects and reducing overall immune system strength?
Dr. Hsu, an expert in using animal models of lupus, reports that activated cells commit suicide when the “TRA-8” antibody binds to “anti-human death receptor 5” (DR5). Few if any scientists have ever studied DR5 as a therapeutic target for accomplishing this—eliminating the specialized cells of the immune system (CD4 and B cells) that lead the charge against foreign pathogens and other invading micro-organisms.
Working with a specialized mouse model, Dr. Hsu and colleagues will test the effectiveness and safety of administering TRA-8 to reduce lupus-causing cells. If successful, she will launch her strategy for rapidly evaluating the approach in humans, through clinical trials.
In an accompanying commentary in JCI, Drs. Claudia Mauri and Madhvi Menon, University College London write that, “The results of this study provide important insight into factors that inhibit AC clearance and promote the development of systemic lupus erythematosus.”
J Clin Invest. 2015 Jul 1;125(7):2877-90. Epub 2015 Jun 22. Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus. Li H, Fu YX, Wu Q, Zhou Y, Crossman DK, Yang P, Li J, Luo B, Morel LM, Kabarowski JH, Yagita H, Ware CF, Hsu HC, Mountz JD.