A subset of white blood cells—plasmacytoid dendritic cells (pDCs)—are likely involved in prompting and mediating the immune system's attack on the body's tissues and organs in lupus.
Up to now, these cells were a challenge to study because they make up such a small part of the total population of white blood cells.
To solve this problem, an LRI researcher is developing a novel mouse model designed to isolate the cells so that their role in lupus can be clarified—and manipulating them becomes a possibility.
Jan Erikson, PhD
The Wistar Institute, Philadelphia, PA
Class of 2006
Another LRI researcher is making breakthroughs in figuring out what activates the dendritic cells.
Ian R. Rifkin, MD, PhD
Boston University School of Medicine, Boston, MA
Class of 2002
Boris Reizis, PhD
Columbia University Medical Center, New York, NY
Class of 2009
Stefania Gallucci, MD
Temple University of the Commonwealth, Philadelphia, PA
Class of 2013
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- B Cells
- Cardiovascular System
- Cell Signaling
- Central Nervous System
- Dendritic Cells
- Environmental Triggers
- Gender Matters
- General Immune System Function
- Human Lupus Biology
- Lupus Pregnancy
- New to Lupus
- New Treatments
- T Cells
- Target Identification
- Why the Lupus Immune System Reacts to Its Own DNA