LRI Researchers Publish Discoveries, Impact Field
Wednesday, June 17, 2009
Recent LRI researcher discoveries published include:
Eric Greidinger, MD (Miami) reports findings on predicting which organs are about to be attacked in lupus in Arthritis and Rheumatism.
Tissue targeting of anti-RNP autoimmunity: effects of T cells and myeloid dendritic cells in a murine model. Greidinger EL, Zang Y, Fernandez I, Berho M, Nassiri M, Martinez L, Hoffman RW. Arthritis Rheum. 2009 Jan 29;60(2):534-542.
Alessandra Pernis, MD (New York) published on clues as to why the body's immune system sometimes turns on its own cells and tissues in Immunity.
RF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Chen Q, Yang W, Gupta S, Biswas P, Smith P, Bhagat G, Pernis AB. Immunity. 2008 Dec;29(6):899-911.
Vicki Rubin Kelley, PhD (Boston) started unraveling the mystery of how sunlight triggers lupus in the Journal of Immunology
Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice. Menke J, Hsu MY, Byrne KT, Lucas JA, Rabacal WA, Croker BP, Zong XH, Stanley ER, Kelley VR. J Immunol. 2008 Nov 15;181(10):7367-79.
Gregory Barton, PhD, (Berkeley, CA) had a breakthrough in understanding basic error of lupus immune system published in Nature
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM. Nature. 2008 Dec 4;456(7222):658-62.
Marko Z Radic, PhD (Memphis) reports on environmental triggers of autoimmunity in the Journal of Innate Immunology
Regulation of Extracellular Chromatin Release from Neutrophils. I Neeli, N Dwivedi, S Khan, M Radic. J Innate Immun 2009 1(3):194-201.
Anne Davidson, MD (Manhassett, NY) reports findings on biomarkers of lupus kidney disease in the Journal of Immunology
Activated renal macrophages are markers of disease onset and disease remission in lupus nephritis. Schiffer L, Bethunaickan R, Ramanujam M, Huang W, Schiffer M, Tao H, Madaio MM, Bottinger EP and A Davidson. J Immunol 2008 180: 1938-1947.
Anne M. Stevens, MD, PhD (Seattle) discloses findings on flawed cell signaling in lupus in Rheumatology.
Active systemic lupus erythematosus is associated with failure of antigen-presenting cells to express programmed death ligand-1. N Mozaffarian, AE Wiedeman, AM Stevens. Rheumatology 2008 47(9):1335-41.
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