Steven Bensinger, VMD, PhD
University of California, Los Angeles, CA
Linking lupus, cardiovascular disease and lipid metabolism
It's still unclear why people with lupus have a more than 50-fold increased risk for cardiovascular problems such as accelerated atherosclerosis
With LRI funding, Dr. Bensinger will pursue the novel concept that a protein called the "Liver X Receptor" (LXR)-already a well-known player in promoting atherosclerosis and inflammation-may also contribute to the accelerated atherosclerosis of lupus.
Dr. Bensinger already has reported that a deficiency of LXR in mice leads to the development of lupus-like disease, providing the first evidence that a single transcription factor may regulate the cause and development of both atherosclerosis and autoimmunity.
In further delving into these tantalizing links between lipid metabolism and inflammation, Dr. Bensinger seeks to uncover a role for LXR as a novel drug target for preventing and treating lupus atherosclerosis.
On the go?
Text INFO to 50555 and opt-in to receive breaking news about lupus on your mobile phone.
Message and Data Rates May Apply. Text STOP to 50555 to STOP. Text HELP to 50555 for HELP. Full Terms
- B Cells
- Cardiovascular System
- Cell Signaling
- Central Nervous System
- Dendritic Cells
- Environmental Triggers
- Gender Matters
- General Immune System Function
- Human Lupus Biology
- Lupus Pregnancy
- New to Lupus
- New Treatments
- T Cells
- Target Identification
- Why the Lupus Immune System Reacts to Its Own DNA