Betty Tsao, PhD
University of California, Los Angeles, CA
2007 Gender Matters
While females are much more likely than males to get lupus—nine women for every one male is affected—illness that does develop in males tends to be particularly severe.
Dr. Tsao has LRI funding to pursue her novel hypothesis on potential genetic defects that may underpin male lupus.
Based in part on several reported cases in which males with lupus carried an extra copy of the X chromosome, Dr. Tsao hypothesizes that X chromosome genetic defects are critical in male lupus.
She is now examining if certain X chromosome genes that already have been implicated in lupus are altered (duplicated, for example) in males with the illness.
Her findings may aid in developing genetic tests for susceptibility to lupus.
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- B Cells
- Cardiovascular System
- Cell Signaling
- Central Nervous System
- Dendritic Cells
- Environmental Triggers
- Gender Matters
- General Immune System Function
- Human Lupus Biology
- Lupus Pregnancy
- New to Lupus
- New Treatments
- T Cells
- Target Identification
- Why the Lupus Immune System Reacts to Its Own DNA